How it works

The essence of PBT® technology lies in maximizing the bioadhesive properties of native chitosan without chemical modifications in its backbone. Structurally, chitosan is a natural polysaccharide composed of monomers of glucosamine and N-acetyl glucosamine. Chitosan gets its cationic (+ve) charge through the protonation of primary amines ( NH 2 ) groups present in its glucosamine subunits. However, this protonation is pH-dependent, at a pH above 6.5 chitosan undergoes neutralization and loses the positive charge at the physiological pH of 7.4. Researchers have developed numerous chemical derivatives of chitosan to improve its cationic properties at physiological conditions. However, such chemical modifications often lead to other drawbacks such as inconsistency, increased processing costs, risk of toxicity, and reduction in chitosan’s molecular weight. Hence, we formulated chitosan with the (PBT®), which only relies on the physical properties and microscopic morphology of this natural material to maximize its cationic charge.

Indications

• Gunshot wounds
• Puncture or Stab wounds
• Blast injuries
• Cuts, Lacerations, Abrasions
• Arterial and Venous bleeding
• Neck and Head Trauma injuries

• Combined effect of bio-adhesion and strong blood clot formation induces instant haemostasis.
• Rapid blood plasma absorption and Entrapment of clotting factors and blood cells in the porous structure due to electrostatic interaction
• Maximization of inherent bio adhesion property of native chitosan without any chemical modification in chitosan backbone
• Creation of a robust seal at the combat injury site due to platelet activation and fibrin formation
• Faster haemostasis than natural blood clotting cascade
• Easy removal from combat injury site due to the neutralization at physiological pH